Colin Cheng

Dr Colin Xinru Cheng

Virologist

Biography

Trained as a virologist, I first studied the curious propensity for dengue virus non-structural protein 5 to localise to the nucleus of infected cells. Now I work with Gulbali Institute researchers studying the interactions between viruses and host nuclear transport pathways, and exploring its potential as a target for antiviral therapy.

Research
  • Arboviruses
  • Structural Biology
  • Host-virus interactions
  • Vector Control
  • Nuclear Transport
Publications
Full publications list on CRO

Recent Publications

  • Cheng, C.X, Tan, M.J.A., Chan, K.W.K., Choy, M.M.J., Roman, N., Arnold, D.D.R., Bifani, A.M., Kong, S.Y.Z., Bist, P., Nath, B.K., Swarbrick, C.M.D., Forwood, J.K., Vasudevan, S.G. (2024). Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization. ACS Infectious Diseases 10:2047-2062.  https://doi.org/10.1021/acsinfecdis.4c00054
  • Cheng CX, Tan MJA, Chan KWK, Watanabe S, Wang S, Choy MM, Manuel M, Victorio CBL, Ong J, Reolo M, Chacko A-M, Vasudevan SG. (2021). In Vitro and In Vivo Stability of P884T, a Mutation that Relocalizes Dengue Virus 2 Non-structural Protein 5. ACS Infectious Diseases 7:3277-3291.
  • Syenina A, Vijaykrishna D, Gan ES, Tan HC, Choy MM, Siriphanitchakorn T, Cheng C, Vasudevan SG, Ooi EE. (2020). Positive epistasis between viral polymerase and the 3′ untranslated region of its genome reveals the epidemiologic fitness of dengue virus. Proceedings of the National Academy of Sciences, 117, 11038-11047
  • Venkataraman, S., Tan, J.P.K., Chong, S.T., Chu, C.Y.H., Wilianto, E.A., Cheng, C.X., Yang, Y.Y. (2019). Identification of Structural Attributes Contributing to the Potency and Selectivity of Antimicrobial Polyionenes: Amides Are Better Than Esters. Biomacromolecules, 20(7), 2737-2742.