Sofiya Tsimbalyuk

Dr Sofiya Tsimbalyuk

Gulbali Research Fellow

Gulbali Institute

Biography

Dr. Sofiya Tsimbalyuk completed a Bachelor of Equine Science and Science (Hons I) at Charles Sturt University, followed by a PhD in Biochemistry and Molecular Biology in 2021 at Professor Forwood's research lab, also at Charles Sturt University. Dr. Tsimbalyuk has been awarded a travel scholarship to present her research at the EAPS 5th Annual EMBL Australia Postgraduate Symposium in Brisbane in 2018. During the symposium, she delivered a seminar on Hendra and Nipah virus proteins. Additionally, she has received multiple Maslen travel scholarships to attend structural biology conferences in Brisbane in 2019 and Wollongong in 2022. She has also been selected to give a seminar as part of the virtual Australian Biochemistry lunch seminar series for early- and mid-career researchers.

Since completing her PhD, Dr. Tsimbalyuk has continued her postdoctoral research in Professor Forwood's lab until 2023. In 2023, she joined the Gulbali Research Institute at Charles Sturt University as a DECRA Track Postdoctoral Fellow, aiming to further her research career. By the end of her contract, she plans to prepare and submit an application for the highly competitive ARC DECRA Fellowship. Dr. Tsimbalyuk has successfully published numerous scientific manuscripts, including in highly regarded journals such as Nature Communications. Through collaboration within national and international research projects, the outcomes of her research have contributed to successful grant applications, including work with NHMRC and NIH.

Dr. Tsimbalyuk's research focuses on investigating the biochemical and physiological mechanisms responsible for biological pest control using probiotic bacteria.

Research
  • Structural and functional characterisation of proteins in health and disease
Publications
Full publications list on CRO

Recent publications

  • Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., Rosnik, A., O’Sullivan, A. M., Davtyan, A., Samudio, B., Thomas, B., Worley, B., Butler, B., Laggner, C., Thayer, D., Moharreri, E., Friedland, G., Truong, H., van den Bedem, H., ... Tsimbalyuk, S., … Heifets, A. (2024). AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports, 14(1), Article 7526. https://doi.org/10.1038/s41598-024-54655-z
  • Tsimbalyuk, S., Cross, E. M., Hoad, M., Donnelly, C. M., Justin, A. R., & Forwood, J. K. (2022). Correction: Tsimbalyuk et al. The Intrinsically Disordered W Protein Is Multifunctional during Henipavirus Infection, Disrupting Host Signalling Pathways and Nuclear Import (Cells 2020, 9, 1913). Cells, 11(8), [1290]. https://doi.org/10.3390/cells11081290
  • Munasinghe, T. S., Edwards, M. R., Tsimbalyuk, S., Vogel, O. A., Smith, K. M., Stewart, M., Foster, J. K., Bosence, L. A., Aragão, D., Roby, J. A., Basler, C. F., & Forwood, J. K. (2022). MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity. Nature Communications, 13(1), [1604]. https://doi.org/10.1038/s41467-022-28851-2
  • Dunn, J., McCuaig, R. D., Tan, A. H. Y., Tu, W. J., Wu, F., Wagstaff, K. M., Zafar, A., Ali, S., Diwakar, H., Dahlstrom, J. E., Bean, E. G., Forwood, J. K., Tsimbalyuk, S., Cross, E. M., Hardy, K., Bain, A. L., Ahern, E., Dolcetti, R., Mazzieri, R., ... Rao, S. (2022). Selective targeting of protein kinase C (PKC)-θ nuclear translocation reduces mesenchymal gene signatures and reinvigorates dysfunctional CD8+ T cells in immunotherapy-resistant and metastatic cancers. Cancers, 14(6), [1596]. https://doi.org/10.3390/cancers14061596
  • Teakel, S., Marama, M., Aragão, D., Tsimbalyuk, S., Mackie, E. R. R., Soares da Costa, T. P., Forwood, J. K., & Cahill, M. A. (2022). Structural characterisation of a MAPR-related archaeal cytochrome b5M protein. FEBS Letters, 596(18), 2409-2417. https://doi.org/10.1002/1873-3468.14471